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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1999 1
2000 1
2003 1
2007 2
2008 2
2009 3
2010 1
2011 7
2012 7
2013 4
2014 6
2015 6
2016 2
2017 4
2018 2
2019 3
2020 8
2021 10
2022 7
2023 3
2024 2

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71 results

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Page 1
Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
Peran I, Dakshanamurthy S, McCoy MD, Mavropoulos A, Allo B, Sebastian A, Hum NR, Sprague SC, Martin KA, Pishvaian MJ, Vietsch EE, Wellstein A, Atkins MB, Weiner LM, Quong AA, Loots GG, Yoo SS, Assefnia S, Byers SW. Peran I, et al. Gastroenterology. 2021 Mar;160(4):1359-1372.e13. doi: 10.1053/j.gastro.2020.11.044. Epub 2020 Dec 9. Gastroenterology. 2021. PMID: 33307028 Free PMC article.
We investigated strategies to disrupt interactions among CAFs, the immune system, and cancer cells, focusing on adhesion molecule CDH11, which has been associated with other fibrotic disorders and is expressed by activated fibroblasts. ...RESULTS: Levels of CDH11 me …
We investigated strategies to disrupt interactions among CAFs, the immune system, and cancer cells, focusing on adhesion molecule …
Pericyte stem cells induce Ly6G(+) cell accumulation and immunotherapy resistance in pancreatic cancer.
Wu Z, Thierry K, Bachy S, Zhang X, Gamradt P, Hernandez-Vargas H, Mikaelian I, Tonon L, Pommier R, Zhao Y, Bertolino P, Hennino A. Wu Z, et al. EMBO Rep. 2023 Apr 5;24(4):e56524. doi: 10.15252/embr.202256524. Epub 2023 Feb 21. EMBO Rep. 2023. PMID: 36802267 Free PMC article.
We report the identification of a cell population that shares pericyte, stromal and stemness features, does not harbor the Kras(G12D) mutation and drives tumoral growth in vitro and in vivo. ...This population induces resistance to anti-PD-1 immunotherapy when coinjected w …
We report the identification of a cell population that shares pericyte, stromal and stemness features, does not harbor the Kras(G12D) …
Molecular Features and Clinical Management of Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.
Kasuga A, Okamoto T, Udagawa S, Mori C, Mie T, Furukawa T, Yamada Y, Takeda T, Matsuyama M, Sasaki T, Ozaka M, Ueki A, Sasahira N. Kasuga A, et al. Int J Mol Sci. 2022 Jan 21;23(3):1205. doi: 10.3390/ijms23031205. Int J Mol Sci. 2022. PMID: 35163129 Free PMC article. Review.
Germline mutations in BRCA1, BRCA2, ATM, PALB2, CDKN2A, STK11, and TP53 and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, and EPCAM) are among the well-known inherited susceptibility genes. Currently available targeted medications include poly (ADP-ribose) polymerase inhi …
Germline mutations in BRCA1, BRCA2, ATM, PALB2, CDKN2A, STK11, and TP53 and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, and EPCAM) …
Pancreatic cancer stem cell markers and exosomes - the incentive push.
Heiler S, Wang Z, Zöller M. Heiler S, et al. World J Gastroenterol. 2016 Jul 14;22(26):5971-6007. doi: 10.3748/wjg.v22.i26.5971. World J Gastroenterol. 2016. PMID: 27468191 Free PMC article. Review.
Furthermore, CSC markers contribute to the generation, loading and delivery of exosomes, whereby CSC gain the capacity for a cell-cell contact independent crosstalk with the host and neighboring non-CSC. This allows Pa-CSC exosomes (TEX) to reprogram neighboring non …
Furthermore, CSC markers contribute to the generation, loading and delivery of exosomes, whereby CSC gain the capacity for a cell- …
Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance.
Katona BW, Klute K, Brand RE, Everett JN, Farrell JJ, Hawthorne K, Kaul V, Kupfer SS, Paiella S, Simeone DM, Sussman DA, Zogopoulos G, Lucas AL, Kastrinos F; PRECEDE Consortium. Katona BW, et al. Cancer Prev Res (Phila). 2023 Jun 1;16(6):343-352. doi: 10.1158/1940-6207.CAPR-22-0529. Cancer Prev Res (Phila). 2023. PMID: 37259800
Of 1,273 HRIs enrolled, 1,113 were eligible for inclusion, with 47.2% meeting familial pancreatic cancer criteria without a known pathogenic variant (PV) and the remainder having a pathogenic variant in a PDAC-risk gene (CDKN2A, STK11, PRSS1, BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, …
Of 1,273 HRIs enrolled, 1,113 were eligible for inclusion, with 47.2% meeting familial pancreatic cancer criteria without a known pathogenic …
Gene-Level Associations in Patients With and Without Pathogenic Germline Variants in CDKN2A and Pancreatic Cancer.
Astiazaran-Symonds E, Graham C, Kim J, Tucker MA, Ingvar C, Helgadottir H, Pastorino L, van Doorn R, Sampson JN, Zhu B, Bruno W, Queirolo P, Fornarini G, Sciallero S, Carter B, Hicks B, Hutchinson A, Jones K, Stewart DR, Chanock SJ, Freedman ND, Landi MT, Höiom V, Puig S, Gruis N, Yang XR, Ghiorzo P, Goldstein AM. Astiazaran-Symonds E, et al. JCO Precis Oncol. 2022 Nov;6:e2200145. doi: 10.1200/PO.22.00145. JCO Precis Oncol. 2022. PMID: 36409970 Free PMC article.
In contrast, the findings in CDKN2A- patients provided evidence for HMBS, EPCAM, and MRE11 as potential new candidate genes and confirmed ATM, BRCA2, and PALB2 as PDAC genes, consistent with findings in The Cancer Genome Atlas and the UKB. ...
In contrast, the findings in CDKN2A- patients provided evidence for HMBS, EPCAM, and MRE11 as potential new candidate genes and confi …
SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer.
Edelman HE, McClymont SA, Tucker TR, Pineda S, Beer RL, McCallion AS, Parsons MJ. Edelman HE, et al. Hum Mol Genet. 2021 Apr 30;30(6):485-499. doi: 10.1093/hmg/ddab064. Hum Mol Genet. 2021. PMID: 33693707 Free PMC article.
Nine of the top 10 downregulated genes have evidence of direct SOX9 binding at their promoter regions. One of these targets was the cancer stem cell marker EpCAM. Using whole-mount in situ hybridization to detect epcam transcript in zebrafish larvae, we demon …
Nine of the top 10 downregulated genes have evidence of direct SOX9 binding at their promoter regions. One of these targets was the cancer s …
Histological and prognostic importance of CD44(+) /CD24(+) /EpCAM(+) expression in clinical pancreatic cancer.
Ohara Y, Oda T, Sugano M, Hashimoto S, Enomoto T, Yamada K, Akashi Y, Miyamoto R, Kobayashi A, Fukunaga K, Morishita Y, Ohkohchi N. Ohara Y, et al. Cancer Sci. 2013 Aug;104(8):1127-34. doi: 10.1111/cas.12198. Epub 2013 Jun 24. Cancer Sci. 2013. PMID: 23679813 Free PMC article.
In view of tumor heterogeneity, we randomly selected 10 high-power fields per case, and triple-positive CD44(+) /CD24(+) /EpCAM(+) expression was identified using our scoring system. The distribution, histological characteristics, and prognostic importance of CD44(+) /CD24 …
In view of tumor heterogeneity, we randomly selected 10 high-power fields per case, and triple-positive CD44(+) /CD24(+) /EpCAM(+) ex …
Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway.
Hao P, Zhang J, Fang S, Jia M, Xian X, Yan S, Wang Y, Ren Q, Yue F, Cui H. Hao P, et al. Hum Cell. 2022 Sep;35(5):1475-1486. doi: 10.1007/s13577-022-00735-z. Epub 2022 Jul 6. Hum Cell. 2022. PMID: 35792978
The exogenous expression of Lcn2 attenuated CSC-associated SOX2, CD44, and EpCAM expression and suppressed sarcosphere formation and tumorigenesis in the pancreatic carcinoma cell line PANC-1, which showed low expression of Lcn2. However, Lcn2 knockout in BxPC-3 …
The exogenous expression of Lcn2 attenuated CSC-associated SOX2, CD44, and EpCAM expression and suppressed sarcosphere formation and …
MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity.
Santoro R, Zanotto M, Carbone C, Piro G, Tortora G, Melisi D. Santoro R, et al. Anticancer Res. 2018 Apr;38(4):1937-1946. doi: 10.21873/anticanres.12431. Anticancer Res. 2018. PMID: 29599309
We hypothesized that MEKK3 could sustain pancreatic cancer by inducing YAP/TAZ oncogenic activities. MATERIALS AND METHODS: In Panc1 and AsPC1 pancreatic cancer cell lines MEKK3 was knocked-out (KO) by the CRISPR/Cas9 method. These cells were used to evaluate MEKK3 contrib …
We hypothesized that MEKK3 could sustain pancreatic cancer by inducing YAP/TAZ oncogenic activities. MATERIALS AND METHODS: In Panc1 and AsP …
71 results